Alternative to, e.g. Diethyl- malonate, permitting selective cleavage of either ester group: t-butyl with mild acid, or ethyl with aqueous alkali. For an example in cephalosporin synthesis, see: J. Antibiot., 39, 1236 (1986). Has also been used in a peptide-type synthesis: Angew. Chem. Int. Ed., 31, 785 (1992); and the synthesis of amino acid derivatives: J. Chem. Soc., Perkin 1, 1053 (1992)